PRO PLAN® Veterinary Supplements Calming Care contains a strain of beneficial bacteria shown to help dogs maintain calm behavior. The science behind our therapeutic products represents a collaboration between Purina nutritionists, researchers and veterinarians. Proprietary use of probiotic strain BL999 to help dogs maintain calm behaviorHelps support dogs with anxious behaviors such as excessive vocalization, jumping, pacing, and spinningHelps dogs cope with external stressors like separation, unfamiliar visitors, novel sounds or changes in routine and locationHelps dogs maintain positive cardiac activity during stressful events